National Ph.D. Meeting

Salerno, Italy
22-24 March 2018



  • Thursday, 22 March

    12:00 Registration
    13:00-14:30 Lunch Buffet
    14:30-16:30 Session 1 • Advanced technology in microscopy, nanotechnology and gene therapy
    Chairs: Francesca Ascenzi and Irene Schiano Lomoriello
    14:30-15:00 Francesca Corsi (Rome)
    Cerium oxide nanoparticles efficiently contrast chemotherapy-induced cancer cells repopulation via COX-2 inhibition
    15:00-15:30 Michela Milani (Milan)
    Liver-directed gene therapy for hemophilia B with immune stealth lentiviral vectors
    15:30-16:00 Giacomo Siano (Pisa)
    Conformation Sensitive Tau: a new biosensor for Tau pathology
    16:00-16:30 Alysia Cox (Monza)
    Evolution of the protein corona across the blood brain barrier
    16:30-19:00 Poster Session I (odd numbers) [with coffee]
    19:00-20:00 Keynote Lecture (sponsored by Leica)
    Chairs: Francesca Ascenzi and Irene Schiano Lomoriello
    Giorgio Modesti
    Super Resolution & Nanoscopy - push the limit of diffraction playing with light
    20:30 Dinner
  • Friday, 23 March

    9:00-10:30 Session 2A • Cancer biology: from molecular mechanism to therapy
    Chairs: Sonia Ciotti and Luciano Nicosia
    9:00-9:30 Andrea Costamagna (Turin)
    ErbB2-p130Cas axis: modeling the interaction to design new potential anticancer agents
    9:30-10:00 Marta Mariniello (Naples)
    Synthetic lethality screening for drugs that overcome ATP7B-mediated tolerance of tumor cells to cisplatin
    10:00-10:30 Giovanni Giangreco (Milan)
    Epsin3 induces a partial EMT state in breast cancer through the regulation of E-Cadherin endocytosis
    10:30-11:00 Coffee break
    11:00-12:30 Session 2B • Cancer biology: from molecular mechanism to therapy
    Chairs: Francescopaolo Iavarone and Irene Schiano Lomoriello
    11:00-11:30 Harikrishnareddy Paluvai (Udine)
    Investigating the oncogenic activities of class IIa HDACs in human cells
    11:30-12:00 Valerio Gelfo (Bologna)
    Molecular mechanisms of resistance to cetuximab mediated by IL1 signaling
    12:00-12:30 Lorenza Bacci (Rome)
    The long non-coding RNA H19 acquires a novel biological function in aggressive prostate cancer upon combination treatment of estrogen and hypoxia
    13:00-14:30 Lunch Buffet
    14:30-17:00 Poster Session II (even numbers) [with coffee]
    17:00-18:30 Session 3 • Differentiation and development
    Chairs: Sonia Ciotti and Francescopaolo Iavarone
    17:00-17:30 Andrea Cirino (Naples)
    ATAC-seq/RNA-seq/ChIP-seq: an epigenetic approach to study Tbx1-chromatin interactions
    17:30-18:00 Valentina Fajner (Milan)
    dHecw, a new member of Drosophila Nedd4 family, regulates RNP particle’s fate during oogenesis
    18:00-18:30 Micaela Lucarelli (Rome)
    Abnormal BDNF signaling in a mouse model of a lysosomal lipid storage disease
    19:00-20:00 Keynote Lecture
    Chairs: Sonia Ciotti and Francescopaolo Iavarone
    Luigi Naldini (Milan)
    Advanced genetic engineering of human hematopoiesis to treat inherited and acquired diseases
    20:30 Dinner
  • Saturday, 24 March

    9:00-10:00 Keynote Lecture
    Chairs: Francesca Ascenzi and Luciano Nicosia
    Pier Giuseppe Pelicci (Milan)
    Adaptive responses of cancer stem cells
    10:00-12:30 Session 4 • Cell biology: signaling and organelle dynamics in physiology and human diseases
    Chairs: Francesca Ascenzi and Luciano Nicosia
    10:00-10:30 Sara Bottone (Naples)
    The extracellular and the transmembrane domain of the same adhesion GPCR act as independent signaling units
    10:30-11:00 Coffee break
    11:00-11:30 Abhishek Derle (Turin)
    Removal of recycling cargo from endosomes requires Rab11 activation on PtdIns(3)P-positive membranes
    11:30-12:00 Nunzia Mollo (Naples)
    PGC-1α as molecular target to restore the mitochondrial network and mitochondrial function in chromosome 21 trisomic cells
    12:00-12:30 Maria Valeria Giuli (Rome)
    Cytotoxic activity of Juglone against Notch3-overexpressing T-cell acute lymphoblastic leukemia: targeting the ER/UPR signalling
    12:30 Prizes for best oral presentation (Luca Daveggio award) and best posters
  • The poster's maximum size is A0 (841 x 1189 mm; width x height).

    Correct format... poster should be PORTRAIT  poster should NOT be LANDSCAPE Wrong format...

    You are expected to have your poster up the latest by 16:30 of Thursday, 22 March. Posters should be taken down at the end of the last poster session on Friday, 23 March, the latest before dinner. Posters left behind will be removed and discarded by the venue personnel.


    • P.1 Vincenza Aliperti (Naples)
      Role of the transcription factor EGR1 in the neuronal survival
      P.3 Marta Borchiellini (Novara)
      RNA-mediated correction of aberrant DNA methylation at the P15 gene locus
      P.5 Francesca Cammarota (Naples)
      HIPK2 depletion promotes cardiac failure in vivo and in vitro
      P.7 Carolina Caserta (Milan)
      MIR-126 describes functionally distinct subclones in primary human B-ALL xenografts: a potent tool to dissect leukemia heterogeneity
      P.9 Martina Castaldo (Naples)
      Tyrosine kinase receptors transactivation: a roadmap toward effective cancer treatment
      P.11 Roberta Chirillo (Catanzaro)
      Ferritin heavy chain regulates miR-125b/p53 axis in non-small cell lung cancer cells
      P.13 Veronica Ciuffoli (Rome)
      TAp63 target genes in myoblasts homeostasis and myogenesis
      P.15 Eva Costanzi (Perugia)
      Identification of carbonylated proteins induced by the neurotoxic action of rotenone in PC12 cells
      P.17 Michela Damizia (Rome)
      A role of SUMO E3 ligase RANBP2 in regulation of kinetochore functions
      P.19 Maria Giovanna de Marino (Busto Arsizio, VA)
      UHRF1: a potential independent factor in CRC?
      P.21 Claudia De Vitis (Rome)
      Lung cancer stem cells (CSC): study of the transcriptional regulation of stearoyl-CoA desaturases-1 gene (SCD1)
      P.23 Giorgia di Blasio (Rome)
      Estrogens modulate chemo sensitivity by modifying subcellular localization of MDM4
      P.25 Veronica Ferrari (Milan)
      VCP: a novel regulator of SOD1-G93A clearance in a ALS model
      P.27 Diletta Fontana (Monza)
      ETNK1 mutations increase mitochondrial activity and promote DNA damage through ROS production
      P.29 Camilla Galli (Milan)
      Dissecting the role of spectrin in cell mechano-adaptation
      P.31 Elena Genovese (Modena)
      Clonal evolution of myeloproliferative neoplasms during leukemia transformation
      P.33 Eugenia Giuliani (Rome)
      Notch3 inactivation increases Triple Negative Breast Cancer sensitivity to gefitinib by promoting EGFR tyrosine dephosphorylation and its intracellular arrest
      P.35 Francescopaolo Iavarone (Naples)
      Cripto modulates angiogenesis and EndMT by controlling the shaping of M2 macrophages in skeletal muscle regeneration
      P.37 Sara Landi (Milan)
      The transcription factor NFIX: a novel modulator of cardiac rhythm in the adult heart
      P.39 Ludovica Lospinoso Severini (Rome)
      Itch/βarrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumourigenesis
      P.41 Maria Mangini (Naples)
      sPLA2-IIA drives osteoclast differentiation and function
      P.43 Domenico Memoli (Baronissi, SA)
      Role of GPAT2 silencing in small RNA landscape in human MDA-MB-231 breast cancer cells.Role of GPAT2 silencing in small RNA landscape in human MDA-MB-231 breast cancer cells
      P.45 Agnese Migliaccio (Naples)
      Collagen hydroxylation drives L-Proline-induced embryonic stem-cell to mesenchymal transition (esMT)
      P.47 Tommaso Montanari (Udine)
      Changes in lipid droplets, mitochondrial morphology and gene expression in SGBS cells
      P.49 Michela Napolitano (Caserta)
      Mechanism of CtBP1-S/BARS-mediated mitotic Golgi fragmentation
      P.51 Luciano Nicosia (Milan)
      Dissection the mechanism of action of LSD1-inhibitors in Acute Myeloid Leukemia by quantitative proteomics
      P.53 Emilia Pascale (Naples)
      A novel ultraconserved element containing long noncoding RNA is required to preserve transcriptional dynamics and maintain embryonic stem cell self-renewal
      P.55 Manpreet Patheja (Naples)
      Mechanism of interaction of Glycerophosphoinositols and Shp1
      P.57 Simona Pellecchia (Naples)
      MPPED2 acts as a tumor suppressor in breast cancer
      P.59 Francesca Perrone (Trieste)
      PDPG Polymer as a targeted delivery system for siRNAs to hepatocellular carcinoma cells
      P.61 Giuseppe Persico (Fano)
      Epigenomic profiling of critical human FFPE-tissues by enhanced PAT-ChIP technique
      P.63 Alessandra Piccirilli (L'Aquila)
      Site-directed mutagenesis of GES β-lactamases: exploring the role of residue 174
      P.65 Federica Polverino (Rome)
      Role of the Aurora-A kinase and its regulator TPX2 in control of spindle orientation in human cells
      P.67 Alberto Quattrocchi (Latina)
      Characterization of CALR 3’UTR functions in normal hematopoiesis
      and myeloproliferative neoplasms
      P.69 Michela Raimondi (Milan)
      Vitamin E-derived tocotrienols: targeting mitochondrial metabolic reprogramming in aggressive tumor cells
      P.71 Roberta Romano (Lecce)
      Expression and role of V1G1 subunit of V-ATPases in breast cancer cells
      P.73 Elisabetta Rubini (Rome)
      Cross-talk between organochlorine pollutants and hormone-resistance in human prostate cancer
      P.75 Giovanna Sabarese (Rome)
      Study of the molecular machinery controlling miRNA sorting in exosomes
      P.77 Pasquale Saggese (Baronissi, SA)
      Biological role of ERβ1 in triple-negative breast cancer
      P.79 Elena Scaglione (Naples)
      Validation of a murine model of meningococcal meningitis with a serogorup C strain and an isogenic unencapsulated mutant
      P.81 Irene Schiano Lomoriello (Milan)
      A novel role of the endocytic protein Epsin3 in breast tumorigenesis through regulation of mammary epithelial stem cells
      P.83 Assunta Sellitto (Baronissi, SA)
      Molecular analysis of the PIWIL1-piRNA system in colon cancer cells
      P.85 Nouha Setti Boubaker (Tunis Cedex, Tunisia)
      The expression of miR-9-5p and LMNA gene in Tunisian patients with Bladder cancer and correlation with clinical parameters
      P.87 Michela Soardi (Padua)
      Novel zebrafish models of sarcoglycanopathy
      P.89 Barbara Tedesco (Milan)
      New HSPB8 mutations related to Amyotrophic Lateral Sclerosis: characterization and impact in cell models of disease
      P.91 Roberta Vazzana (Milan)
      The interplay between fatty acids and glucose metabolism in breast cancer
      P.93 Santina Venuto (San Giovanni Rotondo)
      TRIM8 participates to the mitotic spindle organization: implication in human diseases and cancer
      P.95 Mariateresa Zanobio (Naples)
      MiR-27a functions as a tumour suppressor in t(4;11) leukaemia cells
      P.97 Lucrezia Zerillo (Naples)
      Alteration of endosomal trafficking is associated with early-onset parkinsonism 20
      P.99 Federico Zucca (Milan)
      Characterization and cell cycle implications of astral microtubules regulation by phosphatase Cdc14 and polo-like kinase Cdc5
    • P.2 Sergio Attanasio (Salerno)
      Genetic ablation of Chop decreases hepatic accumulation of mutant Z alpha1-antitrypsin
      P.4 Ornella Brandi (Pavia)
      Role of the ALS linked RNA binding protein TDP-43 in the DNA damage response
      P.6 Natascia Caroccia (Ferrara)
      Exon skipping strategy using modified U7 Sm OPT snRNAs as modulators of pre-mRNA splicing of Mcl-1 to induce apoptotic cell death in cancer cells
      P.8 Daniela Castaldo (Naples)
      Characterization of Lin28 interactors and their role in regulation of mRNA translation
      P.10 Federica Cermola (Naples)
      Impact of the pluripotency states on gastruloids formation ability
      P.12 Sonia Ciotti (Udine)
      Identification of new elements of the proteotoxic-dependent necrotic cell death pathway
      P.14 Cristina Corbetta (Milan)
      Refining strategies for dendritic cell immunotherapy in patients with recurrent glioblastomas
      P.16 Veronica D'Uva (Milan)
      A novel Numb-Mdm2 interaction surface reveals a critical role of Numb isoforms in breast tumorigenesis
      P.18 Monica De Luise (Bologna)
      Absence of mitochondrial antioxidant GLRX2 in familial oncocytic tumors is associated with mtDNA mutations-dependent indolence
      P.20 Roberta De Rosa (Busto Arsizio, VA)
      Molecular mechanisms underlying AMPA-receptor defects in CDKL5 disorder
      P.22 Lucrezia Della Volpe (Milan)
      Crosstalk between DNA damage response activation and inflammation in Hematopoietic Stem and Progenitor cells
      P.24 Stefania Farina (Pavia)
      A role of the ALS-linked protein FUS in the biogenesis of  DNA - Damage induced RNA
      P.26 Claudia Fierro (Rome)
      ΔNp63 regulates the expression of hyaluronic acid-related genes in breast cancer cells
      P.28 Giulia Franzolin (Candiolo, TO)
      PlexinB1 expression in the tumour microenvironment is critically involved in the metastatic dissemination of breast cancer cells
      P.30 Daniela Gatta (Chieti)
      Biological role of licocalcone c on a cellular model of cardiac sepsis: assessment of PI3K/Akt/eNOS and NF-kB/iNOS/NO signaling pathways
      P.32 Flavia Giamogante (Rome)
      The Involvement of STAT3 Post-Translational Modifications in Prostate Cancer Androgen-Resistance
      P.34 Priyanka Gokulnath (Naples)
      PAX8 - a regulator of key pathways in fallopian tube epithelium, site of origin of HGSC?
      P.36 Namrata Iyengar (Naples)
      Unravelling autoregulatory signalling circuits controlling export of different cargo classes from the ER
      P.38 Federica Liccardo (Naples)
      Novel fluorescent probes for precision labeling in super-resolution microscopy
      P.40 Silvia Maiullari (Rome)
      Set-up of an in vivo model of facioscapulohumeral muscular dystrophy (FSHD) based on human perycites
      P.42 Francesca Matteini (Rome)
      Functional interaction between MyoD and PARP1 in the regulation of the
      p57-KvDMR1 locus
      P.44 Marco Meroni (Milan)
      Trehalose and bicalutamide as therapeutic agents of kennedy disease: in vivo studies
      P.46 Ylenia Montalcini (Catanzaro)
      ZNF521 has a regulatory role in ovarian cancer cells
      P.48 Valentina Morra (Pozzuoli, NA)
      Role of OCRL in neurons
      P.50 Francesco Naso (Rome)
      Role of the Aurora-A kinase and its regulator TPX2 in control of chromosome stability in human cells
      P.52 Andrea Orlando (Rome)
      Notch-dependent induction of myeloid derived suppressor cells in T-cell acute lymphoblastic leukemia
      P.54 Margherita Passariello (Naples)
      Novel Human Immunomodulatory Antibodies endowed with T-cell immunostimulatory activity
      P.56 Gaia Pedriali (Ferrara)
      New permeability transition pore inhibitors for the treatment of reperfusion damage
      P.58 Diana Peroni (Busto Arsizio, VA)
      Therapeutic relevance of pregnenolone-based approaches for disorders linked to CDKL5-deficiency
      P.60 Mariasole Perrone (Ferrara)
      Radiation induces IL-1β production and promotes tumor growth in absence of PML
      P.62 Sabrina Petricca (L'Aquila)
      Tebuconazole and Econazole act synergistically in mediating mitochondrial stress and sequential activation of autophagy and apoptosis in mouse Sertoli TM4 cells
      P.64 Consuelo Pitolli (Rome)
      ZNF281 inhibits neuronal differentiation and is a prognostic marker for neuroblastoma
      P.66 Michela Pucci (Bologna)
      Glycosylation in colorectal cancer: role of b4galnt2 and sialyl lewis x antigen
      P.68 Federica Ragusa (L'Aquila)
      Dissecting the role of type 4 phosphodiesterase in human hepatocellular carcinoma
      P.70 Kai Ren (Turin)
      A new biological drug to improve CFTR trafficking and alleviate airway obstruction
      P.72 Lucia Rossi (Rome)
      HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal
      P.74 Ciro Francesco Ruggiero (Catanzaro)
      MiR-579-3p and MITF transcription factor positive feedback loop influences melanoma development and drug resistance
      P.76 Simone Sabbioni (Milan)
      Characterization of the role of a RBX1/FBXW8-based SCF complex in mediating Numb degradation in breast cancer
      P.78 Gennaro Sanità (Naples)
      New drug delivery systems for theranostic applications
      P.80 Stefania Scalise (Catanzaro)
      An integrated proteogenomic analysis of induced pluripotent versus human embryonic stem cells
      P.82 Rossella Scotto di Perrotolo (Milan)
      Molecular basis of myosinVI alternative splicing in cellular transformation
      P.84 Stefania Serpico (Caserta)
      The acyl-glycerol-3-phosphate acyltransferase (AGPAT) enzymes and their role in membrane transport alterations in cancer
      P.86 Diletta Siciliano (Pozzuoli, NA)
      Transcriptional activation of ragD GTPase controls mTORC1 and promotes cancer growth
      P.88 Marco Stazi (Padua)
      A neuronal alarmin triggers specific RNAs, local translation of annexin A2 and cytoskeletal remodeling in schwann cells
      P.90 Rossella Tufano (Naples)
      Evaluation of motility of transformed cell lines with MotoCell
      P.92 Giulia Vecchiotti (L'Aquila)
      Cytotoxicity and inflammatory response induced by tyre particles on macrophages cell line Raw 264.7
      P.94 Megi Vllahu (Fisciano (SA))
      Trefoil Factor 1 and Helicobacter: a close connection
      P.96 Luca Zardoni (Pavia)
      Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription
      P.98 Federica Zinghirino (Catania)
      Regulation of VDACs expression under metabolic stress condition: NRF1 and HIFs transcription factors role




Pier Giuseppe Pelicci

Pier Giuseppe Pelicci is Director of Research of the European Institute of Oncology (IEO) in Milan since 2015, chairman of the Department of Experimental Oncology of IEO since 1995 and full professor of general pathology at the University of Milan since 2004. He is also scientific director of the SEMM Foundation (European School of Molecular Medicine) and president of TTFactor Srl, the technology transfer company of IEO and IFOM (FIRC Institute for Molecular Oncology). He is cofounder and scientific advisor of the biotech holding Genextra which controls five biotech companies (Congenia, DAC, Tethis, Intercept and EryDel). At IEO, Pelicci is responsible for the strategic planning of the institute research programs, including basic, translational and clinical research. Pelicci has made seminal contributions to the study of leukaemia (identification/functional characterization of the PML-RAR and mutated-NPM oncogenes) and to the definition of the molecular basis of its targeted treatment with retinoic acid and histone deacetylase inhibitors. He has also contributed to the elucidation of the molecular basis of aging and aging-associated diseases (Shc protein family). More recently, he has been focusing on the biological and molecular characterization of normal and cancer stem cells, on the mechanisms of DNA damage, and on relapse acquired chemoresistance in acute myeloid leukaemia, using stem-cell based preclinical and clinical models of leukaemia and breast cancer, next generation sequencing technology and RNA interference approaches. His laboratory is also studying the effects of metabolism and specific checkpoint activation on tissue homeostasis, aging and cancer risk (novel signalling pathway involving p53, p66Shc and reactive oxygen species, risk factors such as overweight and obesity). Pelicci is member of different national and international societies, and was honoured with a number of prestigious awards (including several international prizes). He has an extensive publication record (445 peer-reviewed manuscripts, including 377 original research papers, 68 invited reviews and 29 book chapters) with H index = 100. Dr Pelicci is holder of 10 granted patents.

Luigi Naldini

Luigi Naldini received his M.D. from the University of Torino, Italy in 1983 and his Ph.D. from the University of Rome in 1987, carried out post-doctoral work in the U.S.A. with Yossi Schlessinger (1987-89), was visiting scientist with Inder Verma and Didier Trono at the Salk Institute (1994-96), subsequently had independent appointments at Cell Genesys, California (1996-98) and the University of Torino prior to moving to Milan in 2002, where he is currently the Director of the San Raffaele Telethon Institute for Gene Therapy and Professor at the San Raffaele University. In his early career, he identified the ligand for the Met receptor with Hepatocyte Growth Factor. For the last 19 years, Luigi Naldini has pioneered the development and applications of lentiviral vectors for gene transfer, which have become one of the most widely used tool in biomedical research and, upon recently entering clinical testing, are providing a long sought hope of cure for several currently untreatable and otherwise deadly human diseases. Throughout this time he has continued to investigate new strategies to overcome the major hurdles to safe and effective gene transfer, bringing about innovative solutions that not only are being translated into new therapeutic strategies for genetic disease and cancer but have also allowed novel insights into hematopoietic stem cell function, induction of immunological tolerance and tumor angiogenesis. He has published 185 papers in international journals (total Impact Factor 1,905 with average I.F. 10.53 per paper), which have been cited >20,500 times (since 1996; Scopus “h” index: 68). He is the current President of the European Society of Gene and Cell Therapy, member of EMBO since 2008, recipient of an ERC Advanced Investigator Grant and was awarded the Premio Sapio for Italian Research in 2012.