Programme

• THURSDAY, 22 March
• FRIDAY, 23 March
• SATURDAY, 24 March
• POSTERS

• Thursday, 22 March
  12:00	Registration
  13:00-14:30	Lunch Buffet
  14:30-16:30	Session 1 • Advanced technology in microscopy, nanotechnology and gene therapy Chairs: Francesca Ascenzi and Irene Schiano Lomoriello
  14:30-15:00	Francesca Corsi (Rome) Cerium oxide nanoparticles efficiently contrast chemotherapy-induced cancer cells repopulation via COX-2 inhibition
  15:00-15:30	Michela Milani (Milan) Liver-directed gene therapy for hemophilia B with immune stealth lentiviral vectors
  15:30-16:00	Giacomo Siano (Pisa) Conformation Sensitive Tau: a new biosensor for Tau pathology
  16:00-16:30	Alysia Cox (Monza) Evolution of the protein corona across the blood brain barrier
  16:30-19:00	Poster Session I (odd numbers) [with coffee]
  19:00-20:00	Keynote Lecture (sponsored by Leica) Chairs: Francesca Ascenzi and Irene Schiano Lomoriello Giorgio Modesti Super Resolution & Nanoscopy - push the limit of diffraction playing with light
  20:30	Dinner

• Friday, 23 March
  9:00-10:30	Session 2A • Cancer biology: from molecular mechanism to therapy Chairs: Sonia Ciotti and Luciano Nicosia
  9:00-9:30	Andrea Costamagna (Turin) ErbB2-p130Cas axis: modeling the interaction to design new potential anticancer agents
  9:30-10:00	Marta Mariniello (Naples) Synthetic lethality screening for drugs that overcome ATP7B-mediated tolerance of tumor cells to cisplatin
  10:00-10:30	Giovanni Giangreco (Milan) Epsin3 induces a partial EMT state in breast cancer through the regulation of E-Cadherin endocytosis
  10:30-11:00	Coffee break
  11:00-12:30	Session 2B • Cancer biology: from molecular mechanism to therapy Chairs: Francescopaolo Iavarone and Irene Schiano Lomoriello
  11:00-11:30	Harikrishnareddy Paluvai (Udine) Investigating the oncogenic activities of class IIa HDACs in human cells
  11:30-12:00	Valerio Gelfo (Bologna) Molecular mechanisms of resistance to cetuximab mediated by IL1 signaling
  12:00-12:30	Lorenza Bacci (Rome) The long non-coding RNA H19 acquires a novel biological function in aggressive prostate cancer upon combination treatment of estrogen and hypoxia
  13:00-14:30	Lunch Buffet
  14:30-17:00	Poster Session II (even numbers) [with coffee]
  17:00-18:30	Session 3 • Differentiation and development Chairs: Sonia Ciotti and Francescopaolo Iavarone
  17:00-17:30	Andrea Cirino (Naples) ATAC-seq/RNA-seq/ChIP-seq: an epigenetic approach to study Tbx1-chromatin interactions
  17:30-18:00	Valentina Fajner (Milan) dHecw, a new member of Drosophila Nedd4 family, regulates RNP particle’s fate during oogenesis
  18:00-18:30	Micaela Lucarelli (Rome) Abnormal BDNF signaling in a mouse model of a lysosomal lipid storage disease
  19:00-20:00	Keynote Lecture Chairs: Sonia Ciotti and Francescopaolo Iavarone Luigi Naldini (Milan) Advanced genetic engineering of human hematopoiesis to treat inherited and acquired diseases
  20:30	Dinner

• Saturday, 24 March
  9:00-10:00	Keynote Lecture Chairs: Francesca Ascenzi and Luciano Nicosia Pier Giuseppe Pelicci (Milan) Adaptive responses of cancer stem cells
  10:00-12:30	Session 4 • Cell biology: signaling and organelle dynamics in physiology and human diseases Chairs: Francesca Ascenzi and Luciano Nicosia
  10:00-10:30	Sara Bottone (Naples) The extracellular and the transmembrane domain of the same adhesion GPCR act as independent signaling units
  10:30-11:00	Coffee break
  11:00-11:30	Abhishek Derle (Turin) Removal of recycling cargo from endosomes requires Rab11 activation on PtdIns(3)P-positive membranes
  11:30-12:00	Nunzia Mollo (Naples) PGC-1α as molecular target to restore the mitochondrial network and mitochondrial function in chromosome 21 trisomic cells
  12:00-12:30	Maria Valeria Giuli (Rome) Cytotoxic activity of Juglone against Notch3-overexpressing T-cell acute lymphoblastic leukemia: targeting the ER/UPR signalling
  12:30	Prizes for best oral presentation (Luca Daveggio award) and best posters

• The poster's maximum size is A0 (841 x 1189 mm; width x height).

  Correct format...    Wrong format...

  You are expected to have your poster up the latest by 16:30 of Thursday, 22 March. Posters should be taken down at the end of the last poster session on Friday, 23 March, the latest before dinner. Posters left behind will be removed and discarded by the venue personnel.

   

  • THURSDAY, 22 March
  • FRIDAY, 23 March

  • P.1 Vincenza Aliperti (Naples) Role of the transcription factor EGR1 in the neuronal survival

    P.3 Marta Borchiellini (Novara) RNA-mediated correction of aberrant DNA methylation at the P15 gene locus

    P.5 Francesca Cammarota (Naples) HIPK2 depletion promotes cardiac failure in vivo and in vitro

    P.7 Carolina Caserta (Milan) MIR-126 describes functionally distinct subclones in primary human B-ALL xenografts: a potent tool to dissect leukemia heterogeneity

    P.9 Martina Castaldo (Naples) Tyrosine kinase receptors transactivation: a roadmap toward effective cancer treatment

    P.11 Roberta Chirillo (Catanzaro) Ferritin heavy chain regulates miR-125b/p53 axis in non-small cell lung cancer cells

    P.13 Veronica Ciuffoli (Rome) TAp63 target genes in myoblasts homeostasis and myogenesis

    P.15 Eva Costanzi (Perugia) Identification of carbonylated proteins induced by the neurotoxic action of rotenone in PC12 cells

    P.17 Michela Damizia (Rome) A role of SUMO E3 ligase RANBP2 in regulation of kinetochore functions

    P.19 Maria Giovanna de Marino (Busto Arsizio, VA) UHRF1: a potential independent factor in CRC?

    P.21 Claudia De Vitis (Rome) Lung cancer stem cells (CSC): study of the transcriptional regulation of stearoyl-CoA desaturases-1 gene (SCD1)

    P.23 Giorgia di Blasio (Rome) Estrogens modulate chemo sensitivity by modifying subcellular localization of MDM4

    P.25 Veronica Ferrari (Milan) VCP: a novel regulator of SOD1-G93A clearance in a ALS model

    P.27 Diletta Fontana (Monza) ETNK1 mutations increase mitochondrial activity and promote DNA damage through ROS production

    P.29 Camilla Galli (Milan) Dissecting the role of spectrin in cell mechano-adaptation

    P.31 Elena Genovese (Modena) Clonal evolution of myeloproliferative neoplasms during leukemia transformation

    P.33 Eugenia Giuliani (Rome) Notch3 inactivation increases Triple Negative Breast Cancer sensitivity to gefitinib by promoting EGFR tyrosine dephosphorylation and its intracellular arrest

    P.35 Francescopaolo Iavarone (Naples) Cripto modulates angiogenesis and EndMT by controlling the shaping of M2 macrophages in skeletal muscle regeneration

    P.37 Sara Landi (Milan) The transcription factor NFIX: a novel modulator of cardiac rhythm in the adult heart

    P.39 Ludovica Lospinoso Severini (Rome) Itch/βarrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumourigenesis

    P.41 Maria Mangini (Naples) sPLA2-IIA drives osteoclast differentiation and function

    P.43 Domenico Memoli (Baronissi, SA) Role of GPAT2 silencing in small RNA landscape in human MDA-MB-231 breast cancer cells.Role of GPAT2 silencing in small RNA landscape in human MDA-MB-231 breast cancer cells

    P.45 Agnese Migliaccio (Naples) Collagen hydroxylation drives L-Proline-induced embryonic stem-cell to mesenchymal transition (esMT)

    P.47 Tommaso Montanari (Udine) Changes in lipid droplets, mitochondrial morphology and gene expression in SGBS cells

    P.49 Michela Napolitano (Caserta) Mechanism of CtBP1-S/BARS-mediated mitotic Golgi fragmentation

    P.51 Luciano Nicosia (Milan) Dissection the mechanism of action of LSD1-inhibitors in Acute Myeloid Leukemia by quantitative proteomics

    P.53 Emilia Pascale (Naples) A novel ultraconserved element containing long noncoding RNA is required to preserve transcriptional dynamics and maintain embryonic stem cell self-renewal

    P.55 Manpreet Patheja (Naples) Mechanism of interaction of Glycerophosphoinositols and Shp1

    P.57 Simona Pellecchia (Naples) MPPED2 acts as a tumor suppressor in breast cancer

    P.59 Francesca Perrone (Trieste) PDPG Polymer as a targeted delivery system for siRNAs to hepatocellular carcinoma cells

    P.61 Giuseppe Persico (Fano) Epigenomic profiling of critical human FFPE-tissues by enhanced PAT-ChIP technique

    P.63 Alessandra Piccirilli (L'Aquila) Site-directed mutagenesis of GES β-lactamases: exploring the role of residue 174

    P.65 Federica Polverino (Rome) Role of the Aurora-A kinase and its regulator TPX2 in control of spindle orientation in human cells

    P.67 Alberto Quattrocchi (Latina) Characterization of CALR 3’UTR functions in normal hematopoiesis and myeloproliferative neoplasms

    P.69 Michela Raimondi (Milan) Vitamin E-derived tocotrienols: targeting mitochondrial metabolic reprogramming in aggressive tumor cells

    P.71 Roberta Romano (Lecce) Expression and role of V1G1 subunit of V-ATPases in breast cancer cells

    P.73 Elisabetta Rubini (Rome) Cross-talk between organochlorine pollutants and hormone-resistance in human prostate cancer

    P.75 Giovanna Sabarese (Rome) Study of the molecular machinery controlling miRNA sorting in exosomes

    P.77 Pasquale Saggese (Baronissi, SA) Biological role of ERβ1 in triple-negative breast cancer

    P.79 Elena Scaglione (Naples) Validation of a murine model of meningococcal meningitis with a serogorup C strain and an isogenic unencapsulated mutant

    P.81 Irene Schiano Lomoriello (Milan) A novel role of the endocytic protein Epsin3 in breast tumorigenesis through regulation of mammary epithelial stem cells

    P.83 Assunta Sellitto (Baronissi, SA) Molecular analysis of the PIWIL1-piRNA system in colon cancer cells

    P.85 Nouha Setti Boubaker (Tunis Cedex, Tunisia) The expression of miR-9-5p and LMNA gene in Tunisian patients with Bladder cancer and correlation with clinical parameters

    P.87 Michela Soardi (Padua) Novel zebrafish models of sarcoglycanopathy

    P.89 Barbara Tedesco (Milan) New HSPB8 mutations related to Amyotrophic Lateral Sclerosis: characterization and impact in cell models of disease

    P.91 Roberta Vazzana (Milan) The interplay between fatty acids and glucose metabolism in breast cancer

    P.93 Santina Venuto (San Giovanni Rotondo) TRIM8 participates to the mitotic spindle organization: implication in human diseases and cancer

    P.95 Mariateresa Zanobio (Naples) MiR-27a functions as a tumour suppressor in t(4;11) leukaemia cells

    P.97 Lucrezia Zerillo (Naples) Alteration of endosomal trafficking is associated with early-onset parkinsonism 20

    P.99 Federico Zucca (Milan) Characterization and cell cycle implications of astral microtubules regulation by phosphatase Cdc14 and polo-like kinase Cdc5

  • P.2 Sergio Attanasio (Salerno) Genetic ablation of Chop decreases hepatic accumulation of mutant Z alpha1-antitrypsin

    P.4 Ornella Brandi (Pavia) Role of the ALS linked RNA binding protein TDP-43 in the DNA damage response

    P.6 Natascia Caroccia (Ferrara) Exon skipping strategy using modified U7 Sm OPT snRNAs as modulators of pre-mRNA splicing of Mcl-1 to induce apoptotic cell death in cancer cells

    P.8 Daniela Castaldo (Naples) Characterization of Lin28 interactors and their role in regulation of mRNA translation

    P.10 Federica Cermola (Naples) Impact of the pluripotency states on gastruloids formation ability

    P.12 Sonia Ciotti (Udine) Identification of new elements of the proteotoxic-dependent necrotic cell death pathway

    P.14 Cristina Corbetta (Milan) Refining strategies for dendritic cell immunotherapy in patients with recurrent glioblastomas

    P.16 Veronica D'Uva (Milan) A novel Numb-Mdm2 interaction surface reveals a critical role of Numb isoforms in breast tumorigenesis

    P.18 Monica De Luise (Bologna) Absence of mitochondrial antioxidant GLRX2 in familial oncocytic tumors is associated with mtDNA mutations-dependent indolence

    P.20 Roberta De Rosa (Busto Arsizio, VA) Molecular mechanisms underlying AMPA-receptor defects in CDKL5 disorder

    P.22 Lucrezia Della Volpe (Milan) Crosstalk between DNA damage response activation and inflammation in Hematopoietic Stem and Progenitor cells

    P.24 Stefania Farina (Pavia) A role of the ALS-linked protein FUS in the biogenesis of  DNA - Damage induced RNA

    P.26 Claudia Fierro (Rome) ΔNp63 regulates the expression of hyaluronic acid-related genes in breast cancer cells

    P.28 Giulia Franzolin (Candiolo, TO) PlexinB1 expression in the tumour microenvironment is critically involved in the metastatic dissemination of breast cancer cells

    P.30 Daniela Gatta (Chieti) Biological role of licocalcone c on a cellular model of cardiac sepsis: assessment of PI3K/Akt/eNOS and NF-kB/iNOS/NO signaling pathways

    P.32 Flavia Giamogante (Rome) The Involvement of STAT3 Post-Translational Modifications in Prostate Cancer Androgen-Resistance

    P.34 Priyanka Gokulnath (Naples) PAX8 - a regulator of key pathways in fallopian tube epithelium, site of origin of HGSC?

    P.36 Namrata Iyengar (Naples) Unravelling autoregulatory signalling circuits controlling export of different cargo classes from the ER

    P.38 Federica Liccardo (Naples) Novel fluorescent probes for precision labeling in super-resolution microscopy

    P.40 Silvia Maiullari (Rome) Set-up of an in vivo model of facioscapulohumeral muscular dystrophy (FSHD) based on human perycites

    P.42 Francesca Matteini (Rome) Functional interaction between MyoD and PARP1 in the regulation of the p57-KvDMR1 locus

    P.44 Marco Meroni (Milan) Trehalose and bicalutamide as therapeutic agents of kennedy disease: in vivo studies

    P.46 Ylenia Montalcini (Catanzaro) ZNF521 has a regulatory role in ovarian cancer cells

    P.48 Valentina Morra (Pozzuoli, NA) Role of OCRL in neurons

    P.50 Francesco Naso (Rome) Role of the Aurora-A kinase and its regulator TPX2 in control of chromosome stability in human cells

    P.52 Andrea Orlando (Rome) Notch-dependent induction of myeloid derived suppressor cells in T-cell acute lymphoblastic leukemia

    P.54 Margherita Passariello (Naples) Novel Human Immunomodulatory Antibodies endowed with T-cell immunostimulatory activity

    P.56 Gaia Pedriali (Ferrara) New permeability transition pore inhibitors for the treatment of reperfusion damage

    P.58 Diana Peroni (Busto Arsizio, VA) Therapeutic relevance of pregnenolone-based approaches for disorders linked to CDKL5-deficiency

    P.60 Mariasole Perrone (Ferrara) Radiation induces IL-1β production and promotes tumor growth in absence of PML

    P.62 Sabrina Petricca (L'Aquila) Tebuconazole and Econazole act synergistically in mediating mitochondrial stress and sequential activation of autophagy and apoptosis in mouse Sertoli TM4 cells

    P.64 Consuelo Pitolli (Rome) ZNF281 inhibits neuronal differentiation and is a prognostic marker for neuroblastoma

    P.66 Michela Pucci (Bologna) Glycosylation in colorectal cancer: role of b4galnt2 and sialyl lewis x antigen

    P.68 Federica Ragusa (L'Aquila) Dissecting the role of type 4 phosphodiesterase in human hepatocellular carcinoma

    P.70 Kai Ren (Turin) A new biological drug to improve CFTR trafficking and alleviate airway obstruction

    P.72 Lucia Rossi (Rome) HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal

    P.74 Ciro Francesco Ruggiero (Catanzaro) MiR-579-3p and MITF transcription factor positive feedback loop influences melanoma development and drug resistance

    P.76 Simone Sabbioni (Milan) Characterization of the role of a RBX1/FBXW8-based SCF complex in mediating Numb degradation in breast cancer

    P.78 Gennaro Sanità (Naples) New drug delivery systems for theranostic applications

    P.80 Stefania Scalise (Catanzaro) An integrated proteogenomic analysis of induced pluripotent versus human embryonic stem cells

    P.82 Rossella Scotto di Perrotolo (Milan) Molecular basis of myosinVI alternative splicing in cellular transformation

    P.84 Stefania Serpico (Caserta) The acyl-glycerol-3-phosphate acyltransferase (AGPAT) enzymes and their role in membrane transport alterations in cancer

    P.86 Diletta Siciliano (Pozzuoli, NA) Transcriptional activation of ragD GTPase controls mTORC1 and promotes cancer growth

    P.88 Marco Stazi (Padua) A neuronal alarmin triggers specific RNAs, local translation of annexin A2 and cytoskeletal remodeling in schwann cells

    P.90 Rossella Tufano (Naples) Evaluation of motility of transformed cell lines with MotoCell

    P.92 Giulia Vecchiotti (L'Aquila) Cytotoxicity and inflammatory response induced by tyre particles on macrophages cell line Raw 264.7

    P.94 Megi Vllahu (Fisciano (SA)) Trefoil Factor 1 and Helicobacter: a close connection

    P.96 Luca Zardoni (Pavia) Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription

    P.98 Federica Zinghirino (Catania) Regulation of VDACs expression under metabolic stress condition: NRF1 and HIFs transcription factors role